Novel aminoethylbiphenyls as 5-HT7 receptor ligands

Magalie Paillet-Loilier; Frédéric Fabis; Alban Lepailleur; Ronan Bureau; Sabrina Butt-Gueulle; François Dauphin; Aurélien Lesnard; Catherine Delarue; Hubert Vaudry; Sylvain Rault

doi:10.1016/j.bmcl.2007.03.054

Novel aminoethylbiphenyls as 5-HT7 receptor ligands

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22. doi: 10.1016/j.bmcl.2007.03.054. Epub 2007 Mar 23.

Authors

Magalie Paillet-Loilier¹, Frédéric Fabis, Alban Lepailleur, Ronan Bureau, Sabrina Butt-Gueulle, François Dauphin, Aurélien Lesnard, Catherine Delarue, Hubert Vaudry, Sylvain Rault

Affiliation

¹ Centre d'Etudes et de Recherche sur le Médicament de Normandie EA3915, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.

PMID: 17419056
DOI: 10.1016/j.bmcl.2007.03.054

Abstract

The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.

MeSH terms

Aminobiphenyl Compounds / chemical synthesis
Aminobiphenyl Compounds / chemistry*
Aminobiphenyl Compounds / pharmacology
Animals
Humans
Ligands
Rats
Receptors, Serotonin / chemistry*
Receptors, Serotonin / drug effects

Substances

Aminobiphenyl Compounds
Ligands
Receptors, Serotonin
serotonin 7 receptor